Hi, I've pulled together the attached which utilises
1. the BeforeDoubleClick Event {to assist with 'total' question}
2. a (very hidden) Log sheet {to assist with 'resetting' a given region at any point to values as per session start}
What you should find is that you can, via double click on any given yellow cell, initiate the new target / new value entry - and subsequent recalc across remainder of region
if you click Cancel on the first dialog you can confirm a reset -- this will leverage the (very) hidden tab which cached the values when the code first ran, in that session
(use of the alternative Static is more complex given the multiple regions)
as noted, the regions can be modified / reset independent of one another, i.e. you can change B10:B12 without impacting B1:B5 and vice-versa.
There are invariably going to be more elegant / succinct approaches but this is what first came to mind and, hopefully, helps you work through the practicalities of what you're trying to achieve if nothing else.
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