Help! Need help replacing things in a phrase

I know how to replace these individual phrases, with substitute and IF formulas but not sure how to go about the whole thing.

Basically, I want to replace the following letters and colons:

Basically, I want to replace the following letters and colons

Can someone help me in PMs? I keep getting an error that I can't post a link/image/attachment when I try to ask my question but I am not posting any of those..