Compare two cells with comma delimited numbers and display the numbers that are NOT duplic

I have a spreadsheet where cells have a comma delimited collection of numbers that I need to compare:

For example:

The value of A1 = "14, 16, 25, 22, 430, 500"
The value of B1 = "14, 16, 38, 22, 430"

I would like the value of C1 to be, in the same comma delimited format, all the numbers A1 has that B1 does NOT.
I would like the value of D1 to be, in the same comma delimited format, all the numbers B1 has that A1 does NOT.

So based on the example above:

C1 would = "25, 500"
D1 would = "38"


I assume this is too complex to do with a formula, so how would I do this with VBA?

This would need to be repeated for hundreds of lines and ran automatically.