First, the file you attached is not macro-enabled. It would be helpful when you have a file with a macro to post the actual file. Also the data in the attached file does not match your description; it only has two columns of responses.
Here is code that will work for what you described. I don't know where you got Range("l30:cd48") but I changed it to the range you described.
In this case, if the user double-clicks when Option 1 is Yes, then the default action will occur, which is opening the cell for editing. If you do not want to do that, then don't change Cancel to False. Leaving it True will simply result in nothing at all happening after the double-click.
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