I am trying to run a VBS script file, and get Run-Time error '70' Permission denied. This has been very successful in the past (for the same code, and many other) so I do not see it as a vbs code issue. The vbs file is located on an accessible location. But cannot determine the cause or solution. I have simplified the VBS file code to a simple instruction (Msgbox "test") I can manually double-click the file to execute the vbscript, this works successfully (for coded purpose and simple test) Below is the vba code to run the vbs file. Sub testVBS() Dim s As String Dim wshShell As Object ' Run Visual Basic Script file Set wshShell = CreateObject("Wscript.Shell") s = wshShell.Run("""" & "C:\Users\XYZme\Desktop\testmsgbox.vbs" & """", 1, False) End Sub Any assistance to resolve this would be appreciated Unable to add code tags to this post for some reason