What Software Interferes With Excel ??

1 I have noticed is called Wife.exe

No easy way to uninstall, that requires a complete system wipe and reset

Ways around it?
- Never try and force it
- Always agree that what it did was right, and the best way it could ever have been done
- Pay constant attention to it, and do as many nice projects for it as you can
- Keep telling it it looks really good, and is not getting at all bloated from all the code it consumes
- do not - EVER - compare it with any other software out there, it will totally wreck your day/week/month or even your year!

From Wikipedia

IObit Malware Fighter (introduced in 2004) is an anti-malware and anti-virus program for the Microsoft Windows operating system (Windows XP and later). It is designed to remove and protect against malware, including Trojans, rootkits, and ransomware.
------------
Critical reception
In November 2011, the free and paid versions of IObit Malware Fighter were reviewed by Bright Hub, in which the reviewer was unable to recommend the product, citing poor malware protection.
In May 2013, IObit Malware Fighter received a "dismal" score, half a star out of five, for its paid version by PC Magazine.
In December 2013, the paid version of IObit Malware Fighter received a 1 out of 5 star rating from Softpedia.
In March 2015, the commercial version of IObit Malware Fighter 3 received a negative review from PC Magazine, with the reviewer calling the product "useless".
IObit Malware Fighter received a 4 out of 5 star editors rating on CNET's Download.com.
In May 2017, PC Magazine gave the paid version of IObit Malware Fighter a 2 out of 5 star rating.
In July 2017, TechRadar gave the IObit Malware Fighter paid version a two and a half star rating, in which the reviewer complained about the product's overall protection against malware.
In May 2018, IObit Malware Fighter 6 received a negative review from ReviewedByPro.com website with the reviewer stating that the software "is not capable on protecting the entire family, or heavy internet users as the defenses are not very reliable and security features do not work well"

I have two machines at home, winxp/office 2007 & win10/office 2016. I use:
Norton Security,
Spybot Search & Destroy (I do not use the "immunize" feature)
Malwarebytes Premium