What works faster?

Hey you there experts,

So, what works faster and meets best the standards?

If var1 = var2 Then
    If var3 = var4 Then
        If var5 = var6 Then
            'Do something HERE
        End If
        'Nothing Happens
    End If
    'Nothing Happens
End If

OR

If var1 = var2 And var3 = var4 And var5 = var6 Then
    'Do something HERE
End If

What would be the best option if the results are the same?

Thanks