making code more efficient

I started building a large template in excel several months ago when I was very new to VBA. Since then, I've started to pay more attention to making my macros more efficient, so I'm currently going over my old code and trying to rework it to make the whole file smaller and quicker.

My question is if I have a small block of code with only a couple lines like this:

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is it any more or less efficient to write it like this:

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Of course, I understand that the difference may be negligible for one small block of code, but if I have 50-100 similar to this throughout my workbook, is it worth it to go change them all?

Thank you,
JCC

That's great. Thanks for the suggestions - I'll make those changes.

Two more related questions:

1. Is "Application." necessary when writing a block like:

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When is that needed and when is it not? What purpose does it serve?

2. Why is ".Value" preferred over ".FormulaR1C1"? I'm certainly not doubting you... just curious.

Thanks again