Looking for help counting up unique times cell appears in different reference cells

Hi there. Try this out:

=SUM(INDEX(($B$2:$B$21=E3)*($A$2:$A$21<>"")/COUNTIFS($B$2:$B$21,$B$2:$B$21&"",$A$2:$A$21,$A$2:$A$21&""),0))

You're welcome.

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