I think I finally have this right
Trying to keep it as close to the method in post #6, Double click in one of your specified columns to start, then single click the remaining desired cells to add / subtract the values. Single click in a 'between' (C,D,E,H,J,K,etc) column to stop. The results will remain in the sheet until next time you double click.
The code will add a "-" prefix to subtracted values in the cell where the values are listed, if this is not required, replace the line
with
I think it should do what you need it to, guess we will find out shortly
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