Request for VBA code to compare loumns to rows

I have data in 6 columns
1.First I want to find how many columns (from AB1 to AB5) are different for P1 and P2 ,
Eq means: Both P1 and P2 should contain same letters (alleles) or if any one of P1 or P2 contains Z/Z or -/- I should consider them as eq only. Now I am doing this using this formula =IF(D2=D3,"EQ",IF(OR(D2="Z/Z",D2="-/-"),"EQ",IF(OR(D3="Z/Z",D3="-/-"),"EQ","NE")))

2.I will compare lines column values from 1 with P2 across all the columns (from AB1 to AB5) in horizontal way and continue for remaining lines from 2 to 5. if they match I would like to give 1 else 0 and I would like to continue this till my programme encounters second set of P1 and P2. Presently I am doing this with this formula =if(D4=D$3,1,0).

3. I will make sum for lines 1 to 5 across all the columns from columns AB1 to AB5, but I will include only columns showing different for P1 and P2 in my sum count. Now I am working on this with sumif formula.

4.I will calculate percentage of matching lines 1 to 5 with P2 by dividing sum came from SUMIF with number of different markers between P1 and P2.
5. I want to repeat this for remaining set of P1 and P2.
I am expecting like this
LINES XY1 XY2 XY3 XY4 XY5
P1 EQ NE EQ EQ EQ SUM %
P2 1
1 0 0 1 0 0 0 0
2 0 1 0 0 1 1 100
3 0 0 0 0 1 0 0
4 1 0 0 0 0 0 0
5 1 1 0 0 0 1 100

Like this I have data in more than 5000 rows and at present I am doing in excel 2010 with different formulas but it is taking lot of my energy. If anyone provide VBA code for this task I will be more happy and it would be Highly appreciated. I am attaching sample data for better understanding.
Thanking you
Regards,
Genetist.

Dear DonkeyOte,

can you please eloborate your formula i am sorry i did not understand what 250 means and how it influences my calculation if i changes that value to some other value?
Thank you very much